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Posts Tagged ‘colon cancer’

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Pecans—The New Superfood Against Cancer: In this study, extracts of pecan nuts were shown to kill colon cancer cells (up to 90%) and liver cancer cells (up to 70%) more powerfully than any other nut tested, except for walnuts.

We already know that eating nuts is highly protective against cancer and heart disease: just three servings of nuts weekly may cut your risk of cancer death by 40%, and risk of fatal heart disease by a stunning 60% (1 serving = 1 ounce, or 28 grams). But pecans are special because they contain more cancer-fighting antioxidants than almost any other nut: in fact, a single serving of pecans delivers the same antioxidant power as 2,104 mg of vitamin C (yes, over two-thousand mg of vitamin C)!

And the health benefits of pecans don’t stop there: a recent clinical trial showed that adults consuming 68 grams daily of pecans actually saw their total cholesterol and harmful LDL cholesterol significantly decrease after 8 weeks! And another study showed that eating nuts helped overweight women lose weight, decrease hip size, lower their cholesterol and blood sugar, and even lower their blood pressure!

Bottom line: do enjoy a slice of pecan pie this Thanksgiving, but also try to make pecans (and nuts in general), part of a healthy, balanced diet which includes plenty of vegetables, fruit, herbs, and spices.

 

 

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So. There’s a new study comparing the effectiveness of curcumin to chemo drug 5-FU, on colorectal cancer cells.

Curcumin is the active ingredient in Turmeric, one of the top 4 anti-cancer spices that I consumed copious amounts of in 2004, and still consume copious amounts of today.

5-FU, perhaps the most ironically named of all chemo drugs (also known as “5 Feet Under”), is used to treat anal, breast, colorectal, esophageal, pancreatic, stomach and skin cancers (especially head and neck). It was patented in 1957 and is still one the most commonly used cancer drugs today. If that doesn’t send up a red flag about the progress of cancer treatment, your flag pole is broken.

Repeat. One of the most commonly used chemo drugs is almost 60 years old.

Communication between cancer cells and normal cells is a key factor in how cancer progresses. This “signaling” increases the survival, proliferation, and malignant behavior of tumor cells and their ability to resist chemotherapy drugs. In this study, researchers investigated the role of signaling between colon cancer cells and normal cells and how chemotherapy drugs and BCM-95 Curcumin affect that communication.

Additionally, the researchers examined the impact of the treatments on cancer stem cell markers. Cancer stem cells are responsible for developing resistance to chemotherapy and the recurrence of cancer after treatment.

The study used a 3D tumor culture, which more closely replicates how tumors act in the body than other conventional in vitro cell culture models. The culture was treated with either 5‑Fluorouracil (5-FU), which is a common chemotherapeutic agent used for colorectal cancer, BCM-95 Curcumin, or a combination of 5-FU and BCM-95 Curcumin.

Surprise! 5-FU makes cancer stem cells more aggressive

One startling finding of this study was that treatment with 5-FU actually promoted the growth of cancer stem cells, which is the most plausible explanation for why colon cancer usually comes back.

According to Ajay Goel, Ph.D., one of the study’s authors,”Colorectal cancer is especially devastating because of its high recurrence rate. Cancer stem cells exist in very small numbers in a tumor and can hide from chemotherapy… They survive (treatment) and cause cancer to reoccur, sometimes years later. I believe cancer stem cells are the main reason why we can’t stop cancer.”

“Our recent studies on curcumin continue to reveal its unique potential as a therapeutic strategy in the fight against cancer,” continued Dr. Goel. “In this study, treatment with curcumin impeded cancer growth and proliferation by inhibiting signaling proteins and blocking tumor cell promotion. The beauty of curcumin is its ability to balance gene expression and positively influence anticancer pathways.”

Translation: Curcumin slows down and/or stops colon cancer growth and spread. It turns on cancer preventing genes and turns off cancer promoting genes. Friends, this is straight from a very influential and well respected cancer researcher. See his bio at the end of the post.

In the following graph from the study, the grey bars represent the number of cancer cells. The black bars represent the number of CD133 cancer stem cells. As you can see, 5-FU reduced the overall number of cancer cells ~5% more than curcumin, however curcumin dramatically reduced the number of CD133 cancer stem cells compared to 5-FU, which actually caused the cancer stem cells to increase, compared to the untreated cancer cells in the two control groups.

Curcumin vs 5-FU

Curcumin-vs-5-FU

Friends, this graph perfectly demonstrates what is happening in the bodies of thousands of cancer patients. Chemo treatments will shrink the size of a tumor by 50% or more, and this is celebrated as a terrific progress. But meanwhile, the cancer stem cells (the real troublemakers) are multiplying. And soon after chemotherapy treatment is finished, more aggressive chemo-resistant tumors form in new parts of the body.

In this study, cancer growth was inhibited most when the curcumin was used as a pretreatment before chemotherapy. The addition of curcumin sensitized the cancer stem cells to chemotherapy treatment and reduced the amount of 5‑FU needed to inhibit cancer cell growth, but as you can see in the graph, the reduction in cancer stem cells by 5-FU with curcumin was only slightly better (a few percentage points more) than curcumin alone.

And remember, 5-FU was also found to make cancer stem cells more aggressive, which means those 5-FU treated cancer stem cells could become a much more serious problem down the road when compared to the Curcumin treated stem cells.

It is important to note that the form of curcumin used in the study, BCM-95 Curcumin, has unique specifications, including high absorption and inclusion of turmeric essential oil, which is not found in standard curcumin.

Therefore, these specific results may not apply to other forms of curcumin.

The author of this study is Ajay Goel, Ph.D., Director of Epigenetics and Cancer Prevention at Baylor University Medical Center in Dallas, TX. He has spent more than 20 years researching cancer and has been the lead author or contributor to over 150 scientific articles published in peer reviewed international journals and several book chapters. He is currently researching the prevention of gastrointestinal cancers using integrative and alternative approaches, including botanical products. Two of the primary botanicals he is investigating are curcumin (from turmeric) and boswellia.

Dr. Goel is also a member of the American Association for Cancer Research and the American Gastroenterology Association and is on the international editorial boards of Gastroenterology, Clinical Cancer Research, PLoS One, Digestive Diseases and Sciences andWorld Journal of Gastrointestinal Oncology. He also performs peer-reviewing activities for almost 75 scientific journals, as well as serves on various grant funding committees of the National Institutes of Health.

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This is interesting and it comes from a Malaysian-based web site by Dr. Chris KH Teo and his wife Ch’ng Beng Im.

Ten Questions About The World’s Most Well Fought Battle Against Colon Cancer PDF Print E-mail

I give this article the title – the World’s most well fought battle… Why? This is because the man involved in this battle against colon cancer, Tony Snow, used to walk along the corridors of power in the most powerful political office on earth. For many of us in Malaysia, what happens in the United States of America is always the greatest and the best. What America says we agree or have to agree and what America does we follow or eventually have to follow. I would imagine that the most powerful man on earth would be able to do something great to help his beloved staff and fellowman who was in great distress. I believe that Snow would have gotten the best – the best advice, the best doctor, the best drugs and the best hospital – for him to fight his war against cancer. So, to me, this battle against cancer would probably be the most well fought battle ever waged in America – the world’s most powerful nation.

The facts:

  1. Tony Snow was the press secretary for President George Bush – the current (2008) president of the United States of America.
  2. He was married and had three school-going children. His mother also had colon cancer and died when Snow was 17.
  3. Snow was first diagnosed with stage three colon cancer in 2005.
  4. After surgery he underwent six months of chemotherapy.
  5. He was said to be cancer-free after the medical treatments. He was appointed President Bush’s press secretary in May 2006.
  6. In late March 2007, Snow’s cancer reappeared in his abdomen and also his liver.
  7. He underwent surgery in April 2007 followed by more chemotherapy.
  8. Slightly more than a year later, Snow died at the Georgetown University Hospital – on a Saturday morning in July 2008. He was 53 years old.

Read the full article HERE.

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A very lonely place. Outside the operation theaters.

Entrance, Ward 4.

Many a meal taken here, the hospital canteen. And many a friend was made here too. Picture shows the cleaner ladies having their buka puasa. I can count them as my friends now.

No, its not an advertisement for Starbucks. Sept 18 2008. Re-admission to hospital. Re-stitching of the wound that did not quite heal. Two operations in a month, not for the faint of heart nor a body wrecked by cancer.

Sept 26, 2008. Breathing problems, back to ICU for the 2nd time in a month. Doctors make a dire prognosis – “She doesn’t have much time left…” Decision was made to start the B17 protocol, very likely the first time this is being allowed and done in a hospital in the country.

5th day on B17. Dramatic improvement in health, all tubes removed. Here we see the very attentive nurses giving the all smiles.

The B17 protocol stashed away in a little cupboard by the hospital bed. Still, the doctors are very impressed with whatever it is in those bottles. Two doctors express (one in writing on the medical log) “its a miracle.”

Discharged. The Ward 4 nurses make a rare gesture – escorting the patient all the way out to the hospital’s main entrance. Words cannot express the care and attention given by these lovely ladies.

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There are three doctors (and two others with less major roles) who have been attending to Rokiah. The first is the primary surgeon who performed the colon operation. The second is the young surgeon who replaced the primary surgeon when he was on leave for 6 days. The third is the lady respiratory doctor.

It was the young surgeon who on September 30 pulled me aside and told me that Rokiah’s condition was very serious and that “she may not have much time left.” This same surgeon wrote in her medical log a few days later (after the B17 protocol started) that “its a miracle.”

Today, on the eve of her discharge, the doctors made what would be their last visit to Rokiah’s now too familiar hospital bed. The first, the lady doctor, came by when Rokiah was having her breakfast. Besides the usual “how are you today” greeting, she also smiled and knowingly remarked “It’s a miracle, you know.”

The second visitor was the primary surgeon. He came to the ward when the nurse was helping give Rokiah her 9am B17 “medication.” (The B17 regime starts at 7am and ends at 10pm – all in, a total of 9 feedings.) His remark? Nodding to the nurse, the surgeon said “Yes, give her more of that stuff!”

Is this really a miracle?

Time will tell.

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The B17 protocol/regime is much more complex than just swallowing apricot seeds. A pianist is usually the highest paid musician in an orchestra, the star of the ensemble. But without the other musicians in the orchestra, the music is not complete. While B17 is the star of the protocol, the treatment is strongly supported by a highly skilled “orchestra”, made up of 20-25 “musicians” – either a vitamin, supplement or nutrition. Together, they work together to finish off any cancer cell in the body.

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The Ordeal Begins…..

September 4: The long journey from Johor Baru to the hospital near Subang.
September 5: Major colon surgery carried out.
September 13: Discharged from hospital.
September 19: Re-admitted, because of wound infection – fluids discharging from wound.
September 20: 2nd operation in a month to re-stitch the wound.
September 25: Developed breathing problems, doctors are concerned. Returned to ICU and will remain there for another 3 1/2 days. Heart rate: 128-130. Oxygen level (with oxygen aid): 96%
September 28: Back to a normal ward, breathing only slightly improved.
September 29: Doctors express grave concern over her continued gasping for air. One even opined that if the breathing gets worse, everybody should be prepared for the worst.
September 30: With almost no medical options left should the breathing become worse, I made a decision, with the approval of her three doctors, to start B17.

There’s Always Another Option…..

October 1: Hari Raya. Started 19-day B17 protocol/regime.
October 2: Breathing improves. Respiratory doctor expresses surprise at her recovery.
October 3: Heart rate drops from 130 to 110. Swelling in arms disappears.
October 4: Breathing without any oxygen aid. Heart rate: 105, oxygen (on her own steam): 98%.
October 5: All tubes removed except urinal tube (drip tube, oxygen tube, intravenous feeding tube).
October 6: Last tube removed (urinal tube). Stand-by surgeon writes “miracle” in medical log.
October 7: Heart rate: 100, oxygen 98-100%. Starts to walk, with assistance.
October 8: Swollen legs (from Sept 1) subsides completely. Continues with walking exercises.
October 9: Primary surgeon says she can be discharged by October 11. I chose to let her stay one more day in hospital, so that the physio can continue with the walking exercises.

October 12: Discharged.

DO READ: A World Without Cancer

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